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PGD & PGS: what do you need to know

Each parent wants only the best for their child. So just imagine that you have an opportunity to avoid passing critical genetic diseases onto your baby, and ensure their health and safety. World Center of Baby offers this life-changing option to intended parents, and fully controls the entire process and execution. We strongly believe that the dream of parenthood shouldn’t be obstructed by dangerous pathologies and genetic anomalies.

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Definition of PGD and PGS

Preimplantation genetic diagnosis (PGD) is a special type of prenatal genetic screening. The aim is to detect and prevent the transmission of serious diseases, caused by genetic and chromosomal changes, in embryos before implantation to ensure the absence of genetic diseases in the newborn after IVF.

The term preimplantation genetic screening (PGS) or aneuploidy screening, is an adjunct to the PGD and its main goal is to test whether embryos (obtained through IVF/ICSI) have an abnormal number of chromosomes.

The roles of PGD and PGS are of top significance, given that they enable us to select and eliminate any egg/embryo DNA that carry certain mutations for genetic diseases – especially when there is a previous record of chromosomal or genetic disorders in the intended parent’s family.

What are chromosomal and monogenic abnormalities?

It’s a well-known fact that humans have 23 pairs of chromosomes: 22 pairs of autosomes and one pair of sex chromosomes (XX in women and XY in men). When an egg is fertilized by a sperm, each parent gives one chromosome to their child from each pair according to the laws of heredity.

However, sometimes serious changes occur in this process that can lead to genetic transformations. There are two types of these chromosomal abnormalities: numerical (when there are extra or no chromosomes),  and structural – when part of the chromosome is larger, transferred to another one, inverted, or even missing.

When it comes to monogenic abnormalities, the mutation occurs within a specific gene that affects the body's functioning, leading to a disorder. Examples include cystic fibrosis, hemophilia, Huntington’s disease and more.

The worst part is that both types of genetic diseases can be passed on to your offspring.

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When PGD conducting is recommended?

World Center of Baby can help you with an efficient diagnosis of numerical anomalies (or aneuploids), guaranteeing your future child's well-being. Thanks to PGD, intended parents are offered a miraculous chance to avoid such chromosomal aneuploidy that lead to genetic disorders such as Down syndrome (trisomy 21), trisomy 18, trisomy 13, 45X (Turner syndrome), 47XXY (Klinefelter syndrome), 47XYY, and 47XXX.

Preimplantation diagnosis ​​is especially recommended in the following cases:

Preimplantation diagnosis is especially recommended in the following cases:
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The IP is older than 35 years
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The female suffered two or more miscarriages
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The female underwent two or more unsuccessful IVF cycles
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Male factor: abnormal sperm structure
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Couples that are carriers of numerical abnormalities in the sex chromosomes (X or Y)

It is important to understand that a healthy person can be a carrier of chromosomal abnormalities, without visible signs of their presence. In such cases, without external manifestations, they can cause infertility, miscarriage, or disabilities in children.

World Center of Baby fully understands the need to help intended parents with prerequisites to genetic disorders. Therefore, we are dedicating ourselves to combating this problem as far as modern technology will allow, ensuring that more growing families can welcome healthy kids with a bright future. Fill out a brief poll below and our coordinators will be in touch about how you can build a new reality without genetic abnormalities.

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